This article relies largely or entirely on a single source. (February 2019)
Twin-turbo or biturbo refers to a turbocharged engine in which two turbochargers compress the intake charge. The most common layout features two identical turbochargers in parallel; other twin-turbo layouts include sequential and staged turbocharging, the latter of which is used in diesel auto racing applications.
Paralleled twin-turbo refers to the turbocharger configuration in which two identical turbochargers function simultaneously, splitting the turbocharging duties equally. Each turbocharger is driven by half of the engine's spent exhaust energy. In most applications, the compressed air from both turbos is combined in a common intake manifold and sent to the individual cylinders. Usually, each turbocharger is mounted to its own individual exhaust/turbo manifold, but on inline-type engines both turbochargers can be mounted to a single turbo manifold. Parallel twin turbos applied to V-shaped engines are usually mounted with one turbo assigned to each cylinder bank, providing packaging symmetry and simplifying plumbing over a single turbo setup. When used on inline engines, parallel twin turbos are commonly applied with two smaller turbos, which can provide similar performance with less turbo lag than a single larger turbo. Some examples of parallel twin-turbo inline engines are Nissan's RB26DETT, BMW's N54 and Volvo's B6284T and B6294T.
The Maserati Biturbo, introduced in 1981 and featuring an aluminium 90-degree SOHC V6, was the first production car with a twin-turbo charged engine. Other examples of V formation engines with parallel twin-turbos include Mitsubishi's 6A12TT, 6A13TT and 6G72TT; Nissan's VG30DETT and VR38DETT; and Audi's 1997-2002 S4 (B5), 1997-2005 A6, and 2003-2017 RS6.
While a parallel twin-turbo set-up theoretically has less turbo lag than a single turbocharger set up, this is not always the case due to many factors. Marginally reduced combined inertial resistance, simplified exhaust plumbing, and the simultaneous spooling of both turbos means that there can still be a noticeable bit of lag, especially in high-flow turbo/high boost applications. Some ways to counter this are to use a light pressure set up with smaller turbos, where the turbos are designed to output less boost but spool earlier. While this setup sacrifices some top end power, it still has less lag than a similar engine with a single turbo set up making the same power. Another system would be the use of variable geometry turbochargers. This system changes the angle of the guide vanes depending on the exhaust pressure, giving the system excellent power throughout the rev range. Once used mainly in turbocharged diesel engines, Chrysler was the first to use it in mass-production gasoline-powered vehicles with the Shelby CSX, debuted in 1989.
It is possible to use parallel operation with more than two turbochargers. Two such examples are the Bugatti EB110 and Bugatti Veyron, both of which run four turbochargers in parallel. The EB110 runs 4 turbos on a 3.5 litre V12 engine, producing 542 hp (404 kW) at 8000 rpm, while the Veyron uses an 8.0 litre 16 cylinder engine to generate 1,001 PS (736 kW; 987 hp). The Bugatti Veyron Super Sport uses the quad-turbo 8.0 W16 engine that produces 1216 PS (894 kW; 1,200 hp).
Sequential turbos refer to a set-up in which the engine uses one turbocharger for lower engine speeds, and a second or both turbochargers at higher engine speeds. Typically, larger high-flow turbochargers are not as efficient at low RPM, resulting in lower intake manifold pressures under these conditions. On the other hand, smaller turbos spool up quickly at low RPM but cannot supply enough air at higher engine speed. During low to mid engine speeds, when available spent exhaust energy is minimal, only one relatively small turbocharger (called the primary turbocharger) is active. During this period, all of the engine's exhaust energy is directed to the primary turbocharger only, providing the small turbo's benefits of a lower boost threshold, minimal turbo lag, and increased power output at low engine speeds. As RPM increases, the secondary turbocharger is partially activated in order to pre-spool prior to its full utilization. Once a preset engine speed or boost pressure is attained, valves controlling compressor and turbine flow through the secondary turbocharger are opened completely. (The primary turbocharger is deactivated at this point in some applications.) In this way a full twin-turbocharger setup provides the benefits associated with a large turbo, including maximum power output, without the disadvantage of increased turbo lag.
Sequential turbocharger systems provide a way to decrease turbo lag without compromising ultimate boost output and engine power. Perhaps the most noteworthy application of this system is the fourth-generation Toyota Supra (1993-1998), which is generally regarded as having the most reliable sequential turbo system yet fitted to a production automobile, with a reported failure rate of less than 1% as of 2011. Other examples of cars with a sequential twin-turbo setup include the 1986-1988 Porsche 959, the 1990-1995 Eunos Cosmo JC, 1992-2002 Mazda RX-7 FD3S Turbo (13B-REW engine), the 1994-2005 JDM Subaru Legacy GT, GT-B & B4 RSK (EJ20TT engine), and the Peugeot 407 2.2 HDi. GM has filed a patent for a sequential twin-turbo system that uses a new bypass valve design said to optimize exhaust flow to the turbines of both turbochargers.  According to the 2016 patent description, the exhaust manifold features two outlets with one directing exhaust gases to the turbine of the high-pressure turbocharger, while the second exhaust manifold outlet directs exhaust gases to the turbine of the low-pressure turbocharger via a connecting channel. Additionally, exhaust gas exiting the high-pressure turbine is directed to the inlet of the low-pressure turbine. The new bypass system features two throttle valves located on the same spindle mounted perpendicular to each other. With the throttle valves mounted on the same plane, one valve opens to direct exhaust gas flow to one of the turbochargers while the other valves simultaneously blocks exhaust gas flow to the other turbocharger. The vehicle ECU (electronic control unit) sends a signal to the spindle’s actuator to rotate the throttle valves based on rpm and load. GM says the new design allows engineers to optimize exhaust gas flow to both turbines without the compromises of traditional sequential turbocharger systems. Additionally, the system could utilize a variable-geometry turbine or a fixed-geometry turbine on the high-pressure turbo.
A sequential turbo can also be of use to a system where the output pressure must be greater than can be provided by a single turbo, commonly called a staged twin-turbo system. In this case, multiple similarly sized turbochargers are used in sequence, but both operate constantly. The first turbo boosts pressure as much as possible (for example to three times the intake pressure). Subsequent turbos take the charge from the previous stage and compress it further (for example to an additional three times intake pressure, for a total boost of nine times atmospheric pressure). This configuration is commonly found on piston engine aircraft which usually do not need to rapidly raise and lower engine speed (and thus where turbo lag is not a primary design consideration), and where the intake pressure is quite low due to low atmospheric pressure at altitude, requiring a very high pressure ratio. High-performance diesel engines also sometimes use this configuration, since diesel engines do not suffer from pre-ignition issues and can use significantly higher boost pressure than Otto cycle engines.
Advantages in diesel emissions
While spark ignition engines have fallen out of favor of the sequential turbo design, many diesel companies now make engines with sequential turbos in order to reduce emissions.