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Twinrix GlaxoSmithKline - i-hepA & r-hepB-S-Ag - doos Terumo-naald spuiten.JPG

Twinrix is a vaccine against hepatitis A and hepatitis B, manufactured by GlaxoSmithKline. Twinrix is administered over three doses.

The name was created because it is a mixture of two earlier vaccines — Havrix, an inactivated-virus Hepatitis A vaccine, and Engerix-B, a recombinant Hepatitis B vaccine. Twinrix, Havrix and Engerix-B are registered trademarks of GlaxoSmithKline; if the same vaccine is available from others, it will have another name. Twinrix first entered the market in early 1997.[citation needed]

Administration schedule[edit]

Twinrix can be administered on the same schedule as monovalent Hepatitis B vaccine: at 0- 1- and 6- months. In some circumstances, an accelerated dosing schedule of 0- 7- and 21-to 30- days followed by a booster at 12 months can be used and is believed to have similar efficacy as the traditional schedule.[1]


The CDC reports that clinical trials found the following levels of protection against Hep A and Hep B one month after each dose:[2]

A: 93.8%, 98.8%, 99.9%
B: 30.8%, 78.2%, 98.5%

GlaxoSmithKline claims that its studies found 70% of subjects had antibodies against hepatitis B a month after just the first dose, however.[3]

See also[edit]


External links[edit]