Two-hander is a term for a play, movie, or television programme with only two main characters. The two characters in question often display differences in social standing or experiences, differences that are explored and possibly overcome as the story unfolds.
- Vigil by Morris Panych
- The Stronger (1889) by August Strindberg (This play is also an example of a dramatic monologue.)
- Pariah (1889) by August Strindberg
- Two for the Seesaw (1958) by William Gibson
- The Zoo Story (1959) by Edward Albee
- The Dumb Waiter (1960) by Harold Pinter
- The Gin Game (1976) by D.L. Coburn
- Talley's Folly (1980) by Lanford Wilson
- Duet for One (1980, filmed in 1986), by Tom Kempinski
- Educating Rita (1980) by Willy Russell
- Some Men Need Help (1982) by John Ford Noonan
- The Woman in Black (1987) by Stephen Mallatratt
- Love Letters (1988) by A. R. Gurney
- Oleanna (1992) by David Mamet
- john & jen (1995) by Andrew Lippa and Tom Greenwald
- Disco Pigs (1996) by Enda Walsh
- Freud's Last Session (1999) by Mark St. Germain
- The Last Five Years (2001) by Jason Robert Brown
- A Number (2002) by Caryl Churchill
- adrenalin...heart (2002) by Georgia Fitch
- The Story of My Life (2006) by Neil Bartram and Brian Hill
- A Steady Rain (2007) by Keith Huff
- Follow Me (2008) by Ross Gurney-Randall and Dave Mounfield
- it felt empty when the heart went at first but it is alright now (2009) by Lucy Kirkwood
- Red (2009) by John Logan
- Venus in Fur (2010) by David Ives
- In a Forest, Dark and Deep (2011) by Neil LaBute
- Constellations (2012) by Nick Payne
- Between the Sheets (2012) by Jordi Mand
- The Velocity of Autumn (2013) by Eric Coble
- My Dinner with Andre (1981) by Louis Malle
- Sleuth (1972) by Joseph L. Mankiewicz
- Moon (2009) by Duncan Jones
- EastEnders two-hander episodes
- Maude; several episodes (such as "Maude's Night Out" and "The Convention") featured only the characters of Maude and Walter
- In Treatment portrays the relationship between a psychotherapist and his clients, so most episodes are entirely or primarily two-handers.
- Dinner for One (1963) by Lauri Wylie, a one-off TV special traditionally associated with New Year's Eve in central Europe
- "Brian & Stewie", episode of Family Guy
- Four Star Playhouse episode Award, featuring an only two cast members.
- Beirut (1987) by Alan Bowne
- Driving Miss Daisy (1987) by Alfred Uhry
- Lost in Translation (2003)
- Blackbird (2005) by David Harrower
- The Empty Planet (2010)
- Gravity (2013)
- The One I Love (2014)
- Whiplash (2014)
- Ex Machina (2015), by Alex Garland
- "Slanguage Dictionary Results - Two-hander". Variety. Retrieved 2008-06-19.
- Wolcott, James (6 September 2010). "Crouching Duck, Hidden Draper: Mad Men Season 4, Episode 7". Vanity Fair. Retrieved 7 September 2010.
- Caption for still from William Gibson’s play “Two for the Seesaw.” Photo credit Arthur Cantor; from "Looking Back at Arthur Penn" slide show; The New York Times, September 30, 2010. Retrieved 2010-10-04.
- "What's On: Between the Sheets", Nightwood Theatre
- Gussow, Mel, "The Stage: Driving Miss Daisy", The New York Times, April 16, 1987. Retrieved 2011-02-15.