Two-pore channel

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two pore segment channel 1
Symbol TPCN1
Entrez 53373
HUGO 18182
OMIM 609666
RefSeq NM_017901
UniProt Q9ULQ1
Other data
Locus Chr. 12 q24.21
two pore segment channel 2
Symbol TPCN2
Entrez 219931
HUGO 20820
RefSeq NM_139075
UniProt Q8NHX9
Other data
Locus Chr. 11 q13.1

Two-pore channels are a small family of cation-selective ion channels, with two known paralogs in the human genome.[1] They contain two tandem KV-style six-transmembrane domains fused on one polypeptide chain that form a dimers in the membrane.[2][3] These channels are closely related to CatSper channels and, more distantly, to TRP channels.

TPC channels are found in both animal [4] and plant [5] cells. In mammalian cells, recent evidence has identified the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP. The TPCN genes are distinct from the KCNK genes encoding the Tandem pore domain potassium channels.


  1. ^ Yu FH, Catterall WA (October 2004). "The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis". Science's STKE. 2004 (253): re15. doi:10.1126/stke.2532004re15. PMID 15467096. 
  2. ^ Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y (March 2016). "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 196–201. doi:10.1038/nature16446. PMC 4841471Freely accessible. PMID 26689363. 
  3. ^ Kintzer AF, Stroud RM (March 2016). "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 258–62. doi:10.1038/nature17194. PMID 26961658. 
  4. ^ Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632. 
  5. ^ Hedrich R, Neher E (1987). "Cytoplasmic calcium regulates voltage-dependent ion channels in plant vacuoles". Nature. 329: 833–836. doi:10.1038/329833a0. 

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