|two pore segment channel 1|
|Locus||Chr. 12 q24.21|
|two pore segment channel 2|
|Locus||Chr. 11 q13.1|
Two-pore channels are a small family of cation-selective ion channels, with two known paralogs in the human genome. They contain two tandem KV-style six-transmembrane domains fused on one polypeptide chain that form a dimers in the membrane. These channels are closely related to CatSper channels and, more distantly, to TRP channels.
TPC channels are found in both animal  and plant  cells. In mammalian cells, recent evidence has identified the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP. The TPCN genes are distinct from the KCNK genes encoding the Tandem pore domain potassium channels.
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- TPCN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- AtTPC1 channel, Arabidopsis at the US National Library of Medicine Medical Subject Headings (MeSH)
- "CatSper and Two-Pore Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.