This article relies largely or entirely on a single source. (November 2014)
|Chemical and physical data|
|Molar mass||662.788 g·mol−1|
|3D model (JSmol)|
Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides. It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent. It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp (VVYPW).
Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.