Type I collagen

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collagen, type I, alpha 1
Identifiers
SymbolCOL1A1
Entrez1277
HUGO2197
OMIM120150
RefSeqNM_000088
UniProtP02452
Other data
LocusChr. 17 q21.3-q22
collagen, type I, alpha 2
Identifiers
SymbolCOL1A2
Alt. symbolsOI4
Entrez1278
HUGO2198
OMIM120160
RefSeqNM_000089
UniProtP08123
Other data
LocusChr. 7 q21.3-22.1

Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules.

Formation[edit]

The COL1A1 gene produces the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong mature type I collagen fibers.

Clinical significance[edit]

See Collagen, type I, alpha 1#Clinical significance

See also[edit]

External links[edit]

References[edit]

  • Junqueira's Basic Histology, p106