Typhoid vaccine

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Not to be confused with typhus vaccine.
Typhoid vaccine
Vaccine description
Target disease Typhoid
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a607028
ATC code J07AP01 J07AP02 J07AP03
 N (what is this?)  (verify)

Typhoid vaccines are vaccines developed to prevent typhoid fever.

There are two effective types available:[1]

Ty21a is licensed for use from age six years and older. Boosters are recommended every 5 years.[2] The Vi capsular polysaccharide vaccine is licensed for use from age two years and older, and boosters are required every three years.[3]

Almroth Edward Wright developed an effective inactivated whole-cell typhoid vaccine that was introduced in 1896.[4] Due to side-effects its usage was eventually discontinued.[3]

Ty21a and Vi capsular polysaccharide vaccine are effective in reducing typhoid fever with low rates of adverse effects.[5] Newer vaccines such as Vi-rEPA seem promising.[5] It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[6]

Available preparations[edit]


  1. ^ WHO - Typhoid Fever http://www.who.int/ith/vaccines/typhoidfever/en/
  2. ^ http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf
  3. ^ a b c d e Helfand, C; Helfand, C. PaxVax joins the marketed vaccines club with Crucell typhoid buy. FierceVaccines.  Missing |last2= in Authors list (help)
  4. ^ Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261. doi:10.1002/14651858.CD001261.pub2. PMID 17636661. 
  5. ^ a b Anwar, E; Goldberg, E; Fraser, A; Acosta, CJ; Paul, M; Leibovici, L (2 January 2014). "Vaccines for preventing typhoid fever.". The Cochrane database of systematic reviews 1: CD001261. PMID 24385413. 
  6. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.