Tyrosine-protein kinase BLK

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BLK
Identifiers
AliasesBLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDsOMIM: 191305 MGI: 88169 HomoloGene: 1297 GeneCards: BLK
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001715
NM_001330465

NM_007549

RefSeq (protein)

NP_001317394
NP_001706

NP_031575

Location (UCSC)Chr 8: 11.49 – 11.56 MbChr 14: 63.37 – 63.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.[5][6] It is of the Src family of tyrosine kinases.

Interactions[edit]

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.[7]

References[edit]

  1. ^ a b c ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014453 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID 7845672.
  6. ^ "Entrez Gene: BLK B lymphoid tyrosine kinase".
  7. ^ Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. doi:10.1073/pnas.96.17.9557. PMC 22247. PMID 10449731.

Further reading[edit]