|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||285.387 g/mol g·mol−1|
|3D model (JSmol)|
U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes. It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects. It was developed by a team at Upjohn in the 1990s.
- Im, HK; Im, WB; Pregenzer, JF; Carter, DB; Hamilton, BJ (1995). "U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors". The Journal of Pharmacology and Experimental Therapeutics. 275 (3): 1390–5. PMID 8531107.
- Bundy, GL; Ayer, DE; Banitt, LS; Belonga, KL; Mizsak, SA; Palmer, JR; Tustin, JM; Chin, JE; et al. (1995). "Synthesis of novel 2,4-diaminopyrrolo-2,3-dpyrimidines with antioxidant, neuroprotective, and antiasthma activity". Journal of Medicinal Chemistry. 38 (21): 4161–3. doi:10.1021/jm00021a004. PMID 7473542.
- US Patent 5502187 Pharmaceutically active bicyclic-heterocyclic amines
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