U.S. Route 421 in Indiana

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U.S. Route 421 marker

U.S. Route 421
US 421 highlighted in red
Route information
Maintained by INDOT
Length: 232 mi[1] (373 km)
Existed: 1951 – present
Major junctions
South end: US 421 near Madison
  US 50 in Versailles
I-74 Greensburg
I-74 / I-465 in Indianapolis
I-70 in Indianapolis
I-69 in Indianapolis
I-465 in Indianapolis
US 24 in Monticello
US 30 Wanatah
I-80 / I-90 / Indiana Toll Road near Otis
I-94 near Michigan City
North end: US 20 in Michigan City
Counties: Jefferson, Ripley, Decatur, Shelby, Marion, Boone, Clinton, Carroll, White, Pulaski, Starke, LaPorte
Highway system
SR 364 SR 427

U.S. Route 421 (US 421) enters Indiana from Kentucky, proceeding northwest to Indianapolis, joining Interstate 465, and then continuing northwest to Michigan City.

US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital). North of Greensburg, US 421 intersects and merges with I-74 west, through the Shelbyville area en route to Indianapolis. Originally, US 421 followed Southeastern Ave. into downtown Indianapolis, where it merged with US 40 (Washington St.) to West Street, then turned north, following West Street, Northwestern Avenue (later Martin Luther King Jr. Street), and Michigan Road up to the northwest side of the city. US 421 passed an Indianapolis landmark, the Pyramids. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. Originally, the highway's end was a few miles north at the junction with US 12 near the shores of Lake Michigan.

Route description[edit]

Madison to Indianapolis[edit]

US 421 enters Indiana from Kentucky over the Ohio River. After crossing the Ohio River US 421 has a short concurrency with State Road 56 (SR 56). After the concurrency with SR 56 ends US 421 becomes a four-lane highway. US 421 has an intersection with State Road 62 (SR 62). North of Madison US 421 becomes a two-lane highway, heading north then northeast. US 421 heads towards Versailles, passing through an intersection with State Road 250 (SR 250). In Versailles US 421 has a concurrency with State Road 129 that ends at U.S. Route 50 (US 50). US 421 heads west out of Versailles concurrenct with US 50. West of Varsailles US 421 heads northwest, towards Greensburg. US 421 passes through Osgood and Napoleon, passing through intersections with State Road 350 (SR 350) and State Road 48 (SR 48). US 421 enters Greensburg on the southeast side of town and heads to the northwest side of town. In Greensburg US 421 is concurrent with State Road 46 (SR 46) and intersects State Road 3 (SR 3). On the northwest side of Greensburg US 421 joins Interstate 74 (I-74). I-74/US 421 heads northwest towards Indianapolis, passing near Shelbyville. Near Shelbyville I-74/US 421 has interchanges with State Road 44 (SR 44) and State Road 9 (SR 9). I-74/US 421 enters Indianapolis on the southeast side of the city. US 421 heads north and west around Indianapolis, concurrenct with Interstate 465.

Indianapolis to Michigan City[edit]

US 421 is concurrent with I-465, until the northwest side of the city. US 421 leaves I-465 heading northwest. US 421 becomes a two-lane highway, heading through intersections with State Road 32 (SR 32), State Road 47 (SR 47), State Road 38 (SR 38), and State Road 29 (SR 29), and has a concurrency with State Road 28 (SR 28). US 421 and SR 28 enter Frankfort heading west; the concurrency ends when US 421 heads north concurrenct with State Road 38 (SR 38) and State Road 39 (SR 39). US 421/SR 38/SR 39 heads northwest out of Frankfort, and 5 miles (8.0 km) later SR 38 heads due west. US 421/SR 39 heads northwest towards Delphi passing through an intersection with State Road 26 (SR 26). In Delphi US 421/SR 39 are concurrenct with State Road 25 (SR 25). US 421/SR 39 heads northwest out of Delphi passing through Pittsburg. West of Pittsburg US 421/SR 39 heads due north towards Monticello. In Monticello the concurrency with SR 39 ends with SR 39 heading east on U.S. Route 24 and US 421 heading west on US 24. US 24/US 421 heads north towards Reynolds, where US 24 heads west and US 421 heads due north. US 421 heads north towards Michigan City, passing through Monon, Wanatah, and Westville. US 421 has intersections with State Road 16 (SR 16), State Road 114 (SR 114), State Road 143 (SR 143), State Road 8 (SR 8), and U.S. Route 30 (US 30). US 421 has concurrency with State Road 14 (SR 14), State Road 10 (SR 10), U.S. Route 6 (US 6), and State Road 2 (SR 2). US 421 has interchanges with Interstate 80/Interstate 90 and Interstate 94. US 421's northern terminus is at U.S. Route 20 (US 20) in Michigan City.


Before US 421 was commissioned in Indiana, the route from Madison to Boyleston was SR 29. This is why SR 129 and State Road 229 (SR 229) have concurrency or terminus at US 421. US 421 from Reynolds to Michigan City was originally State Road 43 (SR 43). This is the reason for SR 143 having its eastern terminus at US 421.


US 421 passed through downtown Madison and headed northwest out of Madison. A new route was built east of the old route. The old route was designated State Road 107 until it was decommissioned.


US 421 entered Indianapolis on the southeast side of the city and went through downtown. US 421 was routed on Southeastern Avenue, Washington Street, Northwestern Avenue (now Martin Luther King Jr. Street), and Michigan Road.

Michigan City[edit]

US 421 went through Michigan City to U.S. Route 12 (US 12) near Lake Michigan. Then INDOT moved the northern terminus of US 421 south to US 20, on the south side of Michigan City.

Major intersections[edit]

County Location mi[1] km Exit[1] Destinations Notes
Ohio River 0 0.0 Milton-Madison Bridge
US 421 south continues into Kentucky
Jefferson Madison SR 56 east – Aurora Eastern end of SR 56 concurrency
SR 56 west – Hanover Western end of SR 56 concurrency
SR 62 – Hanover, Dillsboro
Ripley Versailles SR 129 south – Vevay Southern end of SR 129 concurrency
US 50 east / SR 129 north – Lawrenceburg Eastern end of US 50 concurrency; northern end of SR 129 concurrency
US 50 west – North Vernon Western end of US 50 concurrency
Osgood SR 350 east – Delaware Western terminus of SR 350
Napoleon SR 48 east – Lawrenceburg Western terminus of SR 48
Decatur Greensburg SR 46 east Eastern end of SR 46 concurrency
SR 46 west – Columbus Western end of SR 46 concurrency
SR 3 – North Vernon, Rushville
132 I-74 east – Cincinnati Eastern end of I-74 concurrency
Shelby Liberty Township 119 SR 244 east Western terminus of SR 244
Shelbyville 116 SR 44 – Franklin, Rushville
113 SR 9 – Shelbyville, Anderson
Marion Indianapolis 94
I-74 / I-465 west / US 31 west / US 36 west
US 40 west / SR 37 south / SR 67 south / Southeastern Ave.
Western end of I-74 concurrency; southern end of I-465/US 31/US 36/US 40/SR 37/SR 67 concurrency
47 US 52 east Southern end of US 52 concurrency
46 US 40 east Northern end of US 40 concurrency
44 I-70 – Indianapolis, Dayton
Lawrence 42 US 36 east / SR 67 north – Pendleton Northern end of US 36/SR 67 concurrency
Indianapolis 37
I-69 north / SR 37 north – Fort Wayne, Noblesville Southern terminus of I-69; northern end of SR 37 concurrency
31 US 31 north – Kokomo, South Bend Northern end of US 31 concurrency
I-465 west – Speedway Northern end of I-465 concurrency
Boone Zionsville SR 334 west Eastern terminus of SR 334
Rosston SR 32 – Lebanon, Noblesville
Marion Township SR 47
Clinton Kirklin SR 38
Michigan Township SR 28 east – Tipton Eastern end of SR 28 concurrency
SR 29 north – Logansport Southern terminus of SR 29
Frankfort SR 28 west / SR 38 south / SR 39 south Western end of SR 28 concurrency; southern end of SR 38/SR 39 concurrency
SR 75 north Southern terminus of SR 75
township line
SR 38 west Northern end of SR 38 concurrency
Rossville SR 26
Carroll Deer Creek Township SR 18 east Eastern end of SR 18 concurrency
Delphi SR 25 north – Logansport Eastern end of SR 25 concurrency
SR 25 south – Lafayette Western end of SR 25 concurrency
Tippecanoe Township SR 18 west Western end of SR 18 concurrency
White Monticello US 24 east / SR 39 north Eastern end of US 24 concurrency; northern end of SR 39 concurrency
Reynolds US 24 west / SR 43 south Western end of US 24 concurrency; northern terminus of SR 43
Monon SR 16
Pulaski Salem Township SR 114 west Eastern terminus of SR 114
White Post Township SR 14 west Southern end of SR 14 concurrency
SR 14 east Northern end of SR 14 concurrency
Cass Township SR 143 west Eastern terminus of SR 143
LaPorte LaCrosse SR 8 – Hebron, Knox
Wanatah US 30 / Lincoln Highway – Merrillville, Valparaiso, Plymouth, Fort Wayne
Westville US 6 east – Walkerton Southern end of US 6 concurrency
US 6 west – Hobart Northern end of US 6 concurrency
SR 2 south – Valparaiso Southern end of SR 2 concurrency
SR 2 north – Laporte Northern end of SR 2 terminus
New Durham Township I-80 / I-90 / Indiana Toll Road – South Bend, Gary, Chicago
Coolspring Township I-94 – Michigan City, Gary, Chicago, Detroit
Michigan City 232 373 US 20 – Michigan City, South Bend, Gary Northern terminus of US 421
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

See also[edit]


  1. ^ a b c "INDOT Roadway Referencing System" (PDF). Indiana Department of Transportation. 

External links[edit]

Route map: Bing / Google

KML is from Wikidata

U.S. Route 421
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