U.S. Route 501 Business in Conway, South Carolina is a former segment of US 501 that runs into downtown Conway. The route begins in Red Hill, and utilizes a flyover with part of the northern terminus of South Carolina Highway 544. The former terminus of SC 544 can be found at the next signalized intersection which is shared with a local street named French Collins Road. Shortly after this, it becomes the western terminus of SC Route 90. The rest of the road runs straight through rural forestland until it approaches the Waccamaw River Memorial Bridge (Main Street Bridge) over the Waccamaw River and after crossing the bridge enters Conway Downtown Historic District. The first major intersection within the district is U.S. Route 378 (Third Street). U.S. Route 701 joins the route in a concurrency at Fourth Avenue, which is also the southwestern terminus of SC 905. North of 4th Avenue US Bus 501/701 passes by more historic sites in the city such as the City Post Office, the Beaty-Little House, the Burroughs School and others. At Collins Park Road/16th Avenue, US 701 continues north along Main Street while Business US 501 turns west, and west of Elm Street curves southwest. US Bus 501 ends at US 501 (Church Street), however 16th Avenue continues as a local street that terminates at US 378.
U.S. Route 501 Business in Marion, South Carolina is a former segment of US 501 that runs into downtown Marion. The route begins south of Marion at a trumpet interchange, which also includes the beginning of a concurrency with SC ALT 41. The next major intersection, SC 576 veers off to the northwest towards Florence. Before the road enters the city, it is named South Main Street. However the road doesn't officially enter the city limits until just south of the Silver Trace Apartment complex, but the surroundings remain mostly residential, although a few commercial properties can be found as you drive further north. US Business 501 becomes a divided highway as it approaches the intersection with US 76(Liberty Street), but only at the southern approach of the intersection. The northwest corner contains a park with an obelisk. Between US 76 and Baptist Street, the west side of US Bus 501 includes a former segment of the road. At Godbold Street, South Main Street becomes North Main Street, which eventually enters the Marion Historic District which includes a former railroad line that's now part of the Marion Hike and Bike Trail. Right after the historic former Marion High School, which is on the NRHP and still the headquarters for the county school district, SC ALT 41 makes a right turn onto Jones Avenue. The road becomes more rural once again as it leaves downtown Marion, and the one last intersection with Paul Road and Meadowview Road exists before the route terminates at another trumpet interchange with US 501.
Established in 1960 when mainline US 501 was bypassed around Laurinburg. US 501 Business, in concurrency partly with US 15 Business and US 401 Business, traverses along Jones Road, Main Street, and Aberdeen Road.
Established in 1960 as a renumbering of mainline US 501, along University Drive and Roxboro Street, through downtown Durham. It is in concurrency with US 15 Business for majority of its route and has relativity unchanged since inception.
U.S. Route 501 Truck (US 501 Truck) is a Truck Detour around US 501 through South Boston. It begins at the intersection of US 58/360 and heads east overlapping those routes until the US 58/360 overlap ends, then turns onto US 360 until it reaches Hamilton Boulevard, heading northwest until finally reaching its parent route.
U.S. Route 501 Business (US 501 Business) is a business route of US 501 in Lynchburg. The highway runs 9.41 miles (15.14 km) from US 29, US 460, and US 501 on the eastern edge of Lynchburg to US 501 on the western edge of Lynchburg. US 501 Business runs concurrently with US 460 Business on Campbell Avenue, a four-lane undivided highway, northwest from the highways' partial cloverleaf interchange with their mainline U.S. Highways and US 29. The business routes meet the northern end of SR 128 (Mayflower Drive) and cross over Norfolk Southern Railway's Blue Ridge District. Just north of the railroad, US 501 Business and US 460 Business veer onto Kemper Avenue, which crosses another rail line and has a cloverleaf interchange with US 29 Business (Lynchburg Expressway); this interchange serves as the northern terminus of US 221. The business routes and US 221 pass through a commercial area and by the Anne Spencer House, then turn west onto 12th Street and cross Norfolk Southern's Danville District rail line a few blocks south of the Lynchburg-Kemper Street Station, which is served by Amtrak.
At Campbell Avenue, US 221 and US 460 Business continue southwest on 12th Street while US 501 Business turns northwest onto Campbell Avenue, which becomes Langhorne Road after the intersection with Park Avenue. The business route intersects SR 163 (Memorial Avenue) at the historic home Centerview. West of Holy Cross Regional Catholic School, US 501 Business leaves the densely populated part of Lynchburg and curves north, passing under a former railroad bridge. West of the Rivermont Historic District, the business route veers onto Rivermont Terrace, then turns west onto Rivermont Avenue, which becomes Boonsboro Road at its intersection with Link Road. US 501 Business continues on Boonsboro Road to its northern terminus at US 501, which heads south on the Lynchburg Expressway and north on the continuation of Boonsboro Road.
U.S. Route 501 Business (US 501 Business) is a business route of US 501 in Buena Vista. The highway runs 0.99 miles (1.59 km) between junctions with US 501 within the city of Buena Vista. When US 501 veers from Magnolia Avenue onto Sycamore Avenue at 16th Street, US 501 Business continues north on Magnolia Avenue, which serves as the main business street of the city. Just south of the Southern Virginia University campus, the business route veers northwest on Park Avenue, which the highway follows to its northern terminus at US 501 (Beech Street) just south of US 501's northern terminus at US 60.
Established in 1957 when mainline US 501 was bypassed west of Sanford. US 501A, in concurrency with US 1A and US 15A, traversed on Carthage Street and Hawkins Avenue. In 1960, it was renumbered as US 501 Business.
Established in 1960 as a renumbering of US 501A along Carthage Street and Hawkins Avenue, in concurrency with US 1 Business and US 15 Business. Between 1976-1978, US 1 Business was rerouted along NC 42 on Wicker Street; it is believed that both US 15 Business and US 501 Business were decommissioned by that time.
Established in 1953 when mainline US 501 was bypassed around Chapel Hill. US 501A, in concurrency with US 15A, traversed on Columbia Street and Franklin Street. In 1960, it was renumbered as US 501 Business.