snRNP70

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SNRNP70
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNRNP70, RNPU1Z, RPU1, SNRP70, Snp1, U1-70K, U170K, U1AP, U1RNP, SnRNP70, small nuclear ribonucleoprotein U1 subunit 70
External IDs MGI: 98341 HomoloGene: 20672 GeneCards: SNRNP70
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SNRNP70
Genomic location for SNRNP70
Band 19q13.33 Start 49,085,419 bp[1]
End 49,108,605 bp[1]
RNA expression pattern
PBB GE SNRP70 201221 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001009820
NM_001301069
NM_003089

NM_009224

RefSeq (protein)

NP_001287998
NP_003080

NP_033250

Location (UCSC) Chr 19: 49.09 – 49.11 Mb Chr 19: 45.38 – 45.4 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[5] that in humans is encoded by the SNRNP70 gene.[6][7] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming part of the spliceosome.

Interactions[edit]

snRNP70 has been shown to interact with ASF/SF2,[8][9] SRPK1,[10][11] and ZRANB2.[12]

Role in autoimmunity[edit]

Antibodies towards snRNP70 are associated with mixed connective tissue disease.[13]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104852 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063511 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Spritz RA, Strunk K, Surowy CS, Hoch SO, Barton DE, Francke U (December 1987). "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding". Nucleic Acids Res. 15 (24): 10373–91. PMC 339950Freely accessible. PMID 2447561. doi:10.1093/nar/15.24.10373. 
  6. ^ "Entrez Gene: SNRP70 small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)". 
  7. ^ Spritz RA, Strunk K, Surowy CS, Mohrenweiser HW (October 1990). "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3". Genomics. 8 (2): 371–9. PMID 2147422. doi:10.1016/0888-7543(90)90295-6. 
  8. ^ Xiao SH, Manley JL (November 1998). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. PMC 1170960Freely accessible. PMID 9799243. doi:10.1093/emboj/17.21.6359. 
  9. ^ Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding". J. Biol. Chem. 273 (32): 20629–35. PMID 9685421. doi:10.1074/jbc.273.32.20629. 
  10. ^ Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (February 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. PMC 2141757Freely accessible. PMID 9472028. doi:10.1083/jcb.140.4.737. 
  11. ^ Kamachi M, Le TM, Kim SJ, Geiger ME, Anderson P, Utz PJ (November 2002). "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 (9): 1213–25. PMC 2194102Freely accessible. PMID 12417631. doi:10.1084/jem.20021167. 
  12. ^ Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. PMC 2196870Freely accessible. PMID 11448987. doi:10.1083/jcb.200010059. 
  13. ^ Sato, T; Fujii, T; Yokoyama, T; Fujita, Y; Imura, Y; Yukawa, N; Kawabata, D; Nojima, T; Ohmura, K; Usui, T; Mimori, T (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.". Arthritis and rheumatism. 62 (12): 3730–40. PMID 20722023. doi:10.1002/art.27700. 

Further reading[edit]