U5 spliceosomal RNA

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U5 spliceosomal RNA
Symbol U5
Rfam RF00020
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO 0000351 0000353 0005682 0046540
SO 0000395

U5 RNA is a non-coding RNA that is a component of both types of known spliceosome.[1] The precise function of this molecule is unknown, though it is known that the 5' loop is required for splice site selection and p220 binding, and that both the 3' stem-loop and the Sm site are important for Sm protein binding and cap methylation.


  1. ^ Hinz M, Moore MJ, Bindereif A (August 1996). "Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assembly". J. Biol. Chem. 271 (31): 19001–19007. doi:10.1074/jbc.271.31.19001. PMID 8702566. 

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