U6atac minor spliceosomal RNA

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U6atac minor spliceosomal RNA
RF00619.jpg
Identifiers
Symbol U6atac
Rfam RF00619
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO 0000355 0000369 0030622 0030627 0005691
SO 0000274

U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type).[1]

U6atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U4atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing.[2] U6atac is the functional analog of U6 spliceosomal RNA in the major U2-type spliceosomal complex.[2]

References[edit]

  1. ^ Lorkovic ZJ, Lehner R, Forstner C, Barta A (2005). "Evolutionary conservation of minor U12-type spliceosome between plants and humans". RNA. 11 (7): 1095–1107. doi:10.1261/rna.2440305. PMC 1370794Freely accessible. PMID 15987817. 
  2. ^ a b Padgett RA, Shukla GC (2002). "A revised model for U4atac/U6atac snRNA base pairing". RNA. 8 (2): 125–128. doi:10.1017/S1355838202017156. PMC 1370236Freely accessible. PMID 11911359. 

External links[edit]