UBE1L

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UBA7
Identifiers
AliasesUBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7
External IDsMGI: 1349462 HomoloGene: 2502 GeneCards: UBA7
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBA7
Genomic location for UBA7
Band3p21.31Start49,805,209 bp[1]
End49,813,953 bp[1]
RNA expression pattern
PBB GE UBE1L 203281 s at fs.png

PBB GE UBE1L 1294 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003335

NM_023738

RefSeq (protein)

NP_003326

n/a

Location (UCSC)Chr 3: 49.81 – 49.81 MbChr 9: 107.98 – 107.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182179 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032596 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme". Proc Natl Acad Sci U S A. 90 (13): 6071–5. doi:10.1073/pnas.90.13.6071. PMC 46869. PMID 8327486.
  6. ^ a b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like".

Further reading[edit]