UBE1L

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UBA7
Identifiers
Aliases UBA7, D8, UBA1B, UBE1L, UBE2, ubiquitin like modifier activating enzyme 7
External IDs MGI: 1349462 HomoloGene: 2502 GeneCards: UBA7
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBA7
Genomic location for UBA7
Band 3p21.31 Start 49,805,207 bp[1]
End 49,813,946 bp[1]
RNA expression pattern
PBB GE UBE1L 203281 s at fs.png

PBB GE UBE1L 1294 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003335

NM_023738

RefSeq (protein)

NP_003326

n/a

Location (UCSC) Chr 3: 49.81 – 49.81 Mb Chr 3: 107.98 – 107.98 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[6]

References[edit]

Further reading[edit]