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Protein UBE2C PDB 1i7k.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs MGI: 1915862 HomoloGene: 5096 GeneCards: 11065
EC number
RNA expression pattern
PBB GE UBE2C 202954 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 20: 45.81 – 45.82 Mb Chr 2: 164.77 – 164.78 Mb
PubMed search [1] [2]
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Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[2]


  1. ^ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200. 
  2. ^ a b "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C". 

Further reading[edit]