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Protein UBE2C PDB 1i7k.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesUBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDsMGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C
EC number2.3.2.24
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for UBE2C
Genomic location for UBE2C
Band20q13.12Start45,812,576 bp[1]
End45,816,957 bp[1]
RNA expression pattern
PBB GE UBE2C 202954 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 20: 45.81 – 45.82 MbChr 2: 164.77 – 164.78 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175063 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001403 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
  6. ^ a b "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading[edit]