UBE2C

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UBE2C
Protein UBE2C PDB 1i7k.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C
EC number 2.3.2.24
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for UBE2C
Genomic location for UBE2C
Band 20q13.12 Start 45,812,576 bp[1]
End 45,816,957 bp[1]
RNA expression pattern
PBB GE UBE2C 202954 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_026785

RefSeq (protein)

NP_081061

Location (UCSC) Chr 20: 45.81 – 45.82 Mb Chr 20: 164.77 – 164.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[6]

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