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Protein UBE2D3 PDB 1ur6.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesUBE2D3, E2(17)KB3, UBC4/5, UBCH5C, ubiquitin conjugating enzyme E2 D3
External IDsOMIM: 602963 MGI: 1913355 HomoloGene: 123914 GeneCards: UBE2D3
EC number2.3.2.24
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for UBE2D3
Genomic location for UBE2D3
Band4q24Start102,794,383 bp[1]
End102,868,896 bp[1]
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC)Chr 4: 102.79 – 102.87 MbChr 3: 135.44 – 135.47 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.[5][6]


The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.[6]


UBE2D3 has been shown to interact with NEDD4.[7][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109332 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078578 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (Dec 1995). "Identification of a family of closely related human ubiquitin conjugating enzymes". The Journal of Biological Chemistry. 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467.
  6. ^ a b "Entrez Gene: UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)".
  7. ^ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes to Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
  8. ^ Wang X, Shi Y, Wang J, Huang G, Jiang X (Sep 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation". The Biochemical Journal. 414 (2): 221–9. doi:10.1042/BJ20080674. PMID 18498243.

Further reading[edit]