From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ubiquitin-conjugating enzyme E2E 3
Protein UBE2E3 PDB 1y6l.png
PDB rendering based on 1y6l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2E3 ; UBCH9; UbcM2
External IDs OMIM604151 MGI107412 HomoloGene4636 GeneCards: UBE2E3 Gene
EC number
RNA expression pattern
PBB GE UBE2E3 210024 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10477 22193
Ensembl ENSG00000170035 ENSMUSG00000027011
UniProt Q969T4 P52483
RefSeq (mRNA) NM_001278554 NM_009454
RefSeq (protein) NP_001265483 NP_033480
Location (UCSC) Chr 2:
180.97 – 181.08 Mb
Chr 2:
78.87 – 78.92 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]


  1. ^ Ito K, Kato S, Matsuda Y, Kimura M, Okano Y (Jun 1999). "cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme". Cytogenet Cell Genet 84 (1-2): 99–104. doi:10.1159/000015229. PMID 10343118. 
  2. ^ a b "Entrez Gene: UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)". 

Further reading[edit]