UBE2E3

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UBE2E3
Protein UBE2E3 PDB 1y6l.png
Identifiers
AliasesUBE2E3, UBCH9, UbcM2, ubiquitin conjugating enzyme E2 E3
External IDsMGI: 107412 HomoloGene: 4636 GeneCards: UBE2E3
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for UBE2E3
Genomic location for UBE2E3
Band2q31.3Start180,967,248 bp[1]
End181,076,585 bp[1]
RNA expression pattern
PBB GE UBE2E3 210024 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278554
NM_001278555
NM_006357
NM_182678

NM_009454
NM_001356395

RefSeq (protein)

NP_001265483
NP_001265484
NP_006348
NP_872619

NP_033480
NP_001343324

Location (UCSC)Chr 2: 180.97 – 181.08 MbChr 2: 78.87 – 78.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170035 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027011 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ito K, Kato S, Matsuda Y, Kimura M, Okano Y (Jun 1999). "cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin-conjugating enzyme". Cytogenet Cell Genet. 84 (1-2): 99–104. doi:10.1159/000015229. PMID 10343118. 
  6. ^ a b "Entrez Gene: UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)". 

Further reading[edit]