UBE2G1

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UBE2G1
Protein UBE2G1 PDB 2awf.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2G1, E217K, UBC7, UBE2G, ubiquitin conjugating enzyme E2 G1
External IDsMGI: 1914378 HomoloGene: 2508 GeneCards: UBE2G1
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for UBE2G1
Genomic location for UBE2G1
Band17p13.2Start4,269,259 bp[1]
End4,366,628 bp[1]
RNA expression pattern
PBB GE UBE2G1 209142 s at fs.png

PBB GE UBE2G1 209141 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182682
NM_003342

NM_025985

RefSeq (protein)

NP_003333

NP_080261

Location (UCSC)Chr 17: 4.27 – 4.37 MbChr 11: 72.61 – 72.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132388 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020794 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Watanabe TK, Kawai A, Fujiwara T, Maekawa H, Hirai Y, Nakamura Y, Takahashi E (Dec 1996). "Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans". Cytogenet Cell Genet. 74 (1–2): 146–8. doi:10.1159/000134403. PMID 8893823.
  6. ^ a b "Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)".

Further reading[edit]