UBE2J1

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UBE2J1
Identifiers
Aliases UBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs MGI: 1926245 HomoloGene: 41090 GeneCards: UBE2J1
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for UBE2J1
Genomic location for UBE2J1
Band 6q15 Start 89,326,625 bp[1]
End 89,352,848 bp[1]
RNA expression pattern
PBB GE UBE2J1 217823 s at fs.png

PBB GE UBE2J1 217825 s at fs.png

PBB GE UBE2J1 217824 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016021

NM_019586
NM_001355494

RefSeq (protein)

NP_057105

NP_062532
NP_001342423

Location (UCSC) Chr 6: 89.33 – 89.35 Mb Chr 6: 33.03 – 33.05 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198833 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028277 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lester D, Farquharson C, Russell G, Houston B (Apr 2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6". Biochem Biophys Res Commun. 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID 10708578. 
  6. ^ a b "Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)". 

Further reading[edit]