UBE2L6

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UBE2L6
Protein UBE2L6 PDB 1wzv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2L6, RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6
External IDs MGI: 1914500 HomoloGene: 3112 GeneCards: 9246
RNA expression pattern
PBB GE UBE2L6 201649 at tn.png

PBB GE UBE2L6 gnf1h10137 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198183
NM_004223

NM_019949

RefSeq (protein)

NP_004214.1
NP_937826.1

NP_064333.2

Location (UCSC) Chr 11: 57.55 – 57.57 Mb Chr 2: 84.8 – 84.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

References[edit]

  1. ^ Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem 272 (21): 13548–54. doi:10.1074/jbc.272.21.13548. PMID 9153201. 
  2. ^ a b "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6". 

Further reading[edit]