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Ubiquitin-conjugating enzyme E2L 6
Protein UBE2L6 PDB 1wzv.png
PDB rendering based on 1wzv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2L6 ; RIG-B; UBCH8
External IDs OMIM603890 MGI1914500 HomoloGene3112 GeneCards: UBE2L6 Gene
EC number
RNA expression pattern
PBB GE UBE2L6 201649 at tn.png
PBB GE UBE2L6 gnf1h10137 at tn.png
More reference expression data
Species Human Mouse
Entrez 9246 56791
Ensembl ENSG00000156587 ENSMUSG00000027078
UniProt O14933 Q9QZU9
RefSeq (mRNA) NM_004223 NM_019949
RefSeq (protein) NP_004214 NP_064333
Location (UCSC) Chr 11:
57.55 – 57.57 Mb
Chr 2:
84.8 – 84.81 Mb
PubMed search [1] [2]

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]


  1. ^ Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem 272 (21): 13548–54. doi:10.1074/jbc.272.21.13548. PMID 9153201. 
  2. ^ a b "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6". 

Further reading[edit]