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Ubiquitin-conjugating enzyme E2M
Protein UBE2M PDB 1y8x.png
PDB rendering based on 1y8x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2M ; UBC-RS2; UBC12; hUbc12
External IDs OMIM603173 MGI108278 HomoloGene2952 GeneCards: UBE2M Gene
EC number
RNA expression pattern
PBB GE UBE2M 203109 at tn.png
More reference expression data
Species Human Mouse
Entrez 9040 22192
Ensembl ENSG00000130725 ENSMUSG00000005575
UniProt P61081 P61082
RefSeq (mRNA) NM_003969 NM_001168469
RefSeq (protein) NP_003960 NP_001161941
Location (UCSC) Chr 19:
58.56 – 58.56 Mb
Chr 7:
13.04 – 13.04 Mb
PubMed search [1] [2]

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.[2]


UBE2M has been shown to interact with NEDD8,[3] PRKAR1A[4] and UBA3.[5]


  1. ^ Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (Aug 1998). "A new NEDD8-ligating system for cullin-4A". Genes Dev 12 (15): 2263–8. doi:10.1101/gad.12.15.2263. PMC 317039. PMID 9694792. 
  2. ^ a b "Entrez Gene: UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)". 
  3. ^ Gong, L; Yeh E T (Apr 1999). "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway". J. Biol. Chem. (UNITED STATES) 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. ISSN 0021-9258. PMID 10207026. 
  4. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.  Cite uses deprecated parameter |coauthors= (help)
  5. ^ Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005). "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1". Mol. Cell 17 (3): 341–50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336. 

Further reading[edit]