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AliasesUBE2O, E2-230K, ubiquitin conjugating enzyme E2 O
External IDsOMIM: 617649 MGI: 2444266 HomoloGene: 11113 GeneCards: UBE2O
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for UBE2O
Genomic location for UBE2O
Band17q25.1Start76,389,456 bp[1]
End76,453,152 bp[1]
RNA expression pattern
PBB GE UBE2O 218141 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 76.39 – 76.45 MbChr 11: 116.54 – 116.58 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.[5][6][7]

UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175931 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020802 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokota T, Nagai H, Harada H, Mine N, Terada Y, Fujiwara H, Yabe A, Miyazaki K, Emi M (Apr 2001). "Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k". Gene. 267 (1): 95–100. doi:10.1016/S0378-1119(01)00407-3. PMID 11311559.
  6. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  7. ^ "Entrez Gene: UBE2O ubiquitin-conjugating enzyme E2O".
  8. ^ Nguyen AT, Prado MA, et al. (2017). "UBE2O remodels the proteome during terminal erythroid differentiation". Science. 357 (6350): eaan0218. doi:10.1126/science.aan0218. PMC 5812729. PMID 28774900.

Further reading[edit]