UBE2R2

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UBE2R2
Identifiers
Aliases UBE2R2, CDC34B, E2-CDC34B, UBC3B, ubiquitin conjugating enzyme E2 R2
External IDs MGI: 1914865 HomoloGene: 3210 GeneCards: UBE2R2
RNA expression pattern
PBB GE UBE2R2 gnf1h07191 s at fs.png

PBB GE UBE2R2 gnf1h00269 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017811

NM_026275

RefSeq (protein)

NP_060281

NP_080551.1
NP_080551

Location (UCSC) Chr 9: 33.82 – 33.92 Mb Chr 4: 41.14 – 41.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.[3][4]

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Semplici F, Meggio F, Pinna LA, Oliviero S (May 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680. 
  4. ^ a b "Entrez Gene: UBE2R2 ubiquitin-conjugating enzyme E2R 2". 

Further reading[edit]