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Ubiquitin-conjugating enzyme E2 variant 1
Protein UBE2V1 PDB 1j74.png
PDB rendering based on 1j74.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2V1 ; CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A
External IDs OMIM602995 MGI1913839 HomoloGene81888 GeneCards: UBE2V1 Gene
Species Human Mouse
Entrez 7335 66589
Ensembl ENSG00000244687 ENSMUSG00000078923
UniProt Q13404 Q9CZY3
RefSeq (mRNA) NM_001032288 NM_023230
RefSeq (protein) NP_001027459 NP_075719
Location (UCSC) Chr 20:
50.08 – 50.12 Mb
Chr 2:
167.61 – 167.63 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.[1][2][3]


Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[3]


UBE2V1 has been shown to interact with UBE2N.[4]


  1. ^ Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM (January 1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol Cell Biol 18 (1): 576–89. PMC 121525. PMID 9418904. 
  2. ^ Rothofsky ML, Lin SL (October 1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter". Gene 195 (2): 141–9. doi:10.1016/S0378-1119(97)00097-8. PMID 9305758. 
  3. ^ a b "Entrez Gene: UBE2V1 ubiquitin-conjugating enzyme E2 variant 1". 
  4. ^ Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (October 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. PMID 11057907. 

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