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Protein UBE2V2 PDB 1j74.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases UBE2V2, DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2, ubiquitin conjugating enzyme E2 V2
External IDs MGI: 1917870 HomoloGene: 55739 GeneCards: 7336
RNA expression pattern
PBB GE UBE2V2 209096 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 48.01 – 48.06 Mb Chr 16: 15.55 – 15.59 Mb
PubMed search [1] [2]
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Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene.[3][4][5]


Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.[5]


UBE2V2 has been shown to interact with HLTF.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM (Jan 1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol. Cell. Biol. 18 (1): 576–89. doi:10.1128/mcb.18.1.576. PMC 121525free to read. PMID 9418904. 
  4. ^ Fritsche J, Rehli M, Krause SW, Andreesen R, Kreutz M (Jul 1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes". Biochem. Biophys. Res. Commun. 235 (2): 407–12. doi:10.1006/bbrc.1997.6798. PMID 9199207. 
  5. ^ a b "Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2". 
  6. ^ Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L (Mar 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824free to read. PMID 18316726. 

Further reading[edit]