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Ubiquitin-conjugating enzyme E2 variant 2
Protein UBE2V2 PDB 1j74.png
PDB rendering based on 1j74.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2V2 ; DDVIT1; DDVit-1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2
External IDs OMIM603001 MGI1917870 HomoloGene55739 ChEMBL: 5235 GeneCards: UBE2V2 Gene
RNA expression pattern
PBB GE UBE2V2 209096 at tn.png
More reference expression data
Species Human Mouse
Entrez 7336 70620
Ensembl ENSG00000169139 ENSMUSG00000022674
UniProt Q15819 Q9D2M8
RefSeq (mRNA) NM_003350 NM_001159351
RefSeq (protein) NP_003341 NP_001152823
Location (UCSC) Chr 8:
48.01 – 48.06 Mb
Chr 16:
15.55 – 15.59 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene.[1][2][3]


Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.[3]


UBE2V2 has been shown to interact with HLTF.[4]


  1. ^ Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M et al. (Jan 1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol. Cell. Biol. 18 (1): 576–89. PMC 121525. PMID 9418904. 
  2. ^ Fritsche J, Rehli M, Krause SW, Andreesen R, Kreutz M (Jul 1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes". Biochem. Biophys. Res. Commun. 235 (2): 407–12. doi:10.1006/bbrc.1997.6798. PMID 9199207. 
  3. ^ a b "Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2". 
  4. ^ Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L et al. (Mar 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824. PMID 18316726. 

Further reading[edit]