Ubiquilin 4

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UBQLN4
Identifiers
AliasesUBQLN4, A1U, A1Up, C1orf6, CIP75, UBIN, Ubiquilin 4
External IDsOMIM: 605440 MGI: 2150152 HomoloGene: 41346 GeneCards: UBQLN4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for UBQLN4
Genomic location for UBQLN4
Band1q22Start156,035,299 bp[1]
End156,053,798 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304342
NM_020131

NM_033526

RefSeq (protein)

NP_001291271
NP_064516

NP_277068

Location (UCSC)Chr 1: 156.04 – 156.05 MbChr 3: 88.55 – 88.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.[5][6][7] Ubiquilin 4 regulates proteasomal protein degradation.[8]

Similarity to Other Proteins[edit]

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160803 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008604 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.
  6. ^ Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.
  7. ^ Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
  8. ^ Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.
  9. ^ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol. 14: 63. doi:10.1186/1471-2148-14-63. PMC 4230246. PMID 24674348.

External links[edit]