UBR1

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UBR1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBR1, JBS, ubiquitin protein ligase E3 component n-recognin 1
External IDs MGI: 1277977 HomoloGene: 7582 GeneCards: 197131
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_174916

NM_009461

RefSeq (protein)

NP_777576.1

NP_033487.2

Location (UCSC) Chr 15: 42.94 – 43.11 Mb Chr 2: 120.86 – 120.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

The human gene UBR1 encodes the enzyme ubiquitin-protein ligase E3 component n-recognin 1.[1][2]

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.[2]

References[edit]

  1. ^ Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A (Aug 1998). "The mouse and human genes encoding the recognition component of the N-end rule pathway". Proc Natl Acad Sci U S A 95 (14): 7898–903. doi:10.1073/pnas.95.14.7898. PMC 20901. PMID 9653112. 
  2. ^ a b "Entrez Gene: UBR1 ubiquitin protein ligase E3 component n-recognin 1". 

Further reading[edit]