UBTF

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UBTF
Protein UBTF PDB 1k99.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBTF, NOR-90, UBF, UBF-1, UBF1, UBF2, upstream binding transcription factor, RNA polymerase I
External IDs MGI: 98512 HomoloGene: 7970 GeneCards: UBTF
RNA expression pattern
PBB GE UBTF 202692 s at fs.png

PBB GE UBTF 214881 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001076683
NM_001076684
NM_014233

NM_001044383
NM_011551
NM_001302954
NM_001302955

RefSeq (protein)

NP_001070151
NP_001070152
NP_055048

n/a

Location (UCSC) Chr 17: 44.21 – 44.22 Mb Chr 11: 102.3 – 102.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.[3][4]

Function[edit]

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM][4]

Interactions[edit]

UBTF has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK (May 1997). "Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496. 
  4. ^ a b "Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I". 
  5. ^ Voit R, Kuhn A, Sander EE, Grummt I (July 1995). "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF". Nucleic Acids Res. 23 (14): 2593–9. doi:10.1093/nar/23.14.2593. PMC 307079Freely accessible. PMID 7651819. 
  6. ^ Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI (October 2000). "Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1". Oncogene. 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686. 
  7. ^ Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092Freely accessible. PMID 11698641. 
  8. ^ Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/mcb.20.16.5930-5938.2000. PMC 86070Freely accessible. PMID 10913176. 
  9. ^ Lin CY, Tuan J, Scalia P, Bui T, Comai L (Dec 2002). "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 (24): 2142–6. doi:10.1016/s0960-9822(02)01389-1. PMID 12498690. 

Further reading[edit]