UBXD5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UBXN11
Identifiers
Aliases UBXN11, COA-1, SOC, SOCI, UBXD5, PP2243, UBX domain protein 11
External IDs MGI: 1914836 HomoloGene: 12159 GeneCards: UBXN11
Genetically Related Diseases
obesity[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183008
NM_001077262
NM_145345

NM_026257

RefSeq (protein)

NP_001070730
NP_663320
NP_892120

NP_080533.1
NP_080533

Location (UCSC) Chr 1: 26.28 – 26.32 Mb Chr 4: 134.1 – 134.13 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.[4][5]

Function[edit]

This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Interactions[edit]

UBXD5 has been shown to interact with Rnd1,[4] Rnd2[4] and Rnd3.[4]

References[edit]

Further reading[edit]