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UCSC may refer to:
- Università Cattolica del Sacro Cuore, an Italian private research university founded in 1921
- University of California, Santa Cruz, a public, collegiate research university and one of 10 campuses in the University of California system
- The UCSC Genome Browser, a genetics website and database
- University of Colombo School of Computing, a higher educational institute affiliated to the University of Colombo in Sri Lanka
- Catholic University of the Holy Conception (Universidad Católica de la Santísima Concepción), a university in Chile and part of the Chilean Traditional Universities
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