In enzymology, an UDP-glucuronate 5'-epimerase (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction
- UDP-glucuronate UDP-L-iduronate
Hence, this enzyme has one substrate, UDP-glucuronate, and one product, UDP-L-iduronate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucuronate 5'-epimerase. Other names in common use include uridine diphosphoglucuronate 5'-epimerase, UDP-glucuronic acid 5'-epimerase, and C-5-uronosyl epimerase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, NAD+.
- Jacobson B; Davidson EA (1962). "Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase". J. Biol. Chem. 237: 638–642. PMID 14450717.