From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases UGCG, GCS, GLCT1, UDP-glucose ceramide glucosyltransferase
External IDs MGI: 1332243 HomoloGene: 37763 GeneCards: UGCG
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for UGCG
Genomic location for UGCG
Band 9q31.3 Start 111,896,766 bp[1]
End 111,935,369 bp[1]
RNA expression pattern
PBB GE UGCG 221765 at fs.png

PBB GE UGCG 204881 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 111.9 – 111.94 Mb Chr 9: 59.19 – 59.22 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.[5][6][7]

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.[7]


UGCG has been shown to interact with RTN1 .[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148154 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028381 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–43. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331Freely accessible. PMID 8643456. 
  6. ^ Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–4. doi:10.1159/000134731. PMID 9605861. 
  7. ^ a b "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase". 
  8. ^ Di Sano, Federica; Fazi Barbara; Citro Gennaro; Lovat Penny E; Cesareni Gianni; Piacentini Mauro (Jul 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. United States. 63 (14): 3860–5. ISSN 0008-5472. PMID 12873973. 

Further reading[edit]