UGT1A10

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UGT1A10
Identifiers
Aliases UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J, UDP glucuronosyltransferase family 1 member A10
External IDs HomoloGene: 133281 GeneCards: 54575
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019075

n/a

RefSeq (protein)

NP_061948.1

n/a

Location (UCSC) Chr 2: 233.64 – 233.77 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

UDP-glucuronosyltransferase 1-10 is an enzyme that in humans is encoded by the UGT1A10 gene.[1][2][3]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359". 

References[edit]

  1. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054. 
  2. ^ Mojarrabi B, Mackenzie PI (Oct 1997). "The human UDP glucuronosyltransferase, UGT1A10, glucuronidates mycophenolic acid". Biochem Biophys Res Commun 238 (3): 775–8. doi:10.1006/bbrc.1997.7388. PMID 9325166. 
  3. ^ a b "Entrez Gene: UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10". 

Further reading[edit]