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AliasesUGT1A5, UDPGT, UDPGT 1-5, UGT1E, UDP glucuronosyltransferase family 1 member A5
External IDsHomoloGene: 117984 GeneCards: UGT1A5
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for UGT1A5
Genomic location for UGT1A5
Band2q37.1Start233,712,992 bp[1]
End233,773,299 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 233.71 – 233.77 Mbn/a
PubMed search[2]n/a
View/Edit Human

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.[3][4][5]


This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.[3]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240224 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ a b "Entrez Gene: UDP glucuronosyltransferase 1 family".
  4. ^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. PMID 1339448.
  5. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.