UGT1A8

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UGT1A8
Identifiers
AliasesUGT1A8, UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP glucuronosyltransferase family 1 member A8, UGT1-01, UGT-1A, UGT1.1, UGT1A, hUG-BR1, UGT1, GNT1, UGT1A1
External IDsMGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A8
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for UGT1A8
Genomic location for UGT1A8
Band2q37.1Start233,617,645 bp[1]
End233,773,310 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019076

NM_201644

RefSeq (protein)

NP_061949

NP_964006

Location (UCSC)Chr 2: 233.62 – 233.77 MbChr 1: 88.07 – 88.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.[5][6][7]

Function[edit]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242366 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. PMID 1339448.
  6. ^ Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.
  7. ^ "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.