UHRF2

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UHRF2
Protein UHRF2 PDB 1wy8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDs MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152896

NM_144873

RefSeq (protein)

NP_690856

NP_659122.2
NP_659122

Location (UCSC) Chr 9: 6.41 – 6.51 Mb Chr 19: 30.03 – 30.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[3][4]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013. 
  4. ^ a b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2". 

Further reading[edit]