ULBP2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ULBP2
Identifiers
Aliases ULBP2, N2DL2, RAET1H, ALCAN-alpha, NKG2DL2, UL16 binding protein 2
External IDs HomoloGene: 130743 GeneCards: ULBP2
RNA expression pattern
PBB GE ULBP2 221291 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025217

n/a

RefSeq (protein)

NP_079493

n/a

Location (UCSC) Chr 6: 149.94 – 149.95 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.[2][3] ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus.[2][3] The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.[2][3] It functions as a stress-induced ligand for NKG2D receptor.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ a b c Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445. 
  3. ^ a b c d Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464. 

Further reading[edit]