ULK1

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ULK1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1
External IDs MGI: 1270126 HomoloGene: 2640 GeneCards: 8408
RNA expression pattern
PBB GE ULK1 209333 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003565

NM_009469

RefSeq (protein)

NP_003556.1

NP_033495.2

Location (UCSC) Chr 12: 131.89 – 131.92 Mb Chr 5: 110.78 – 110.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.[3][4]

Function[edit]

ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis.

Interactions[edit]

ULK1 has been shown to interact with GABARAPL2,[5] GABARAP,[5][6] SYNGAP1[7] and SDCBP.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T (Jul 1998). "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment". Genomics. 51 (1): 76–85. doi:10.1006/geno.1998.5340. PMID 9693035. 
  4. ^ "Entrez Gene: ULK1 unc-51-like kinase 1 (C. elegans)". 
  5. ^ a b Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1-2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101. 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948free to read. PMID 17353931. 
  7. ^ a b Tomoda T, Kim JH, Zhan C, Hatten ME (Mar 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes & Development. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236free to read. PMID 15014045. 

Further reading[edit]