- ATP + UMP ADP + UDP
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:UMP phosphotransferase. Other names in common use include uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, and SmbA. This enzyme participates in pyrimidine metabolism.
As of March 2010, 19 structures have been solved for this class of enzymes, and are deposited in the PDB. All have a 3-layer (aba) sandwich) architecture (CATH code 3.40.1160.10). These include accession codes 2J4J, 2J4K, 2J4L, and 2VA1.
- Gilles AM, Barzu O (1995). "Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP". Biochemistry. 34 (15): 5066–5074. doi:10.1021/bi00015a018. PMID 7711027.
- Marco-Marin C, Gil-Ortiz F, Rubio V (2005). "The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis". J. Mol. Biol. 352 (2): 438–454. doi:10.1016/j.jmb.2005.07.045. PMID 16095620.
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