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Unc-5 homolog C (C. elegans)
Symbols UNC5C ; UNC5H3
External IDs OMIM603610 MGI1095412 HomoloGene2765 GeneCards: UNC5C Gene
RNA expression pattern
PBB GE UNC5C 206189 at tn.png
More reference expression data
Species Human Mouse
Entrez 8633 22253
Ensembl ENSG00000182168 ENSMUSG00000059921
UniProt O95185 O08747
RefSeq (mRNA) NM_003728 NM_001293561
RefSeq (protein) NP_003719 NP_001280490
Location (UCSC) Chr 4:
96.08 – 96.47 Mb
Chr 3:
141.47 – 141.83 Mb
PubMed search [1] [2]

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.[1][2][3]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.[3]


  1. ^ Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature 386 (6627): 833–8. doi:10.1038/386833a0. PMID 9126742. 
  2. ^ Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics 52 (2): 205–8. doi:10.1006/geno.1998.5425. PMID 9782087. 
  3. ^ a b "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)". 

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