UNC5C

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UNC5C
Identifiers
Aliases UNC5C, UNC5H3, unc-5 netrin receptor C
External IDs MGI: 1095412 HomoloGene: 2765 GeneCards: UNC5C
RNA expression pattern
PBB GE UNC5C 206189 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003728

NM_001293561
NM_009472

RefSeq (protein)

NP_003719

NP_001280490
NP_033498

Location (UCSC) Chr 4: 95.16 – 95.55 Mb Chr 3: 141.47 – 141.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.[3][4][5]

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M (May 1997). "Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors". Nature. 386 (6627): 833–8. PMID 9126742. doi:10.1038/386833a0. 
  4. ^ Ackerman SL, Knowles BB (Dec 1998). "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23". Genomics. 52 (2): 205–8. PMID 9782087. doi:10.1006/geno.1998.5425. 
  5. ^ a b "Entrez Gene: UNC5C unc-5 homolog C (C. elegans)". 

Further reading[edit]