UNC93A Identifiers Aliases , Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A UNC93A External IDs MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Gene location (Mouse) Chr. Chromosome 17 (mouse)  Band 17 A1|17 8.78 cM Start 13,108,617 bp  End 13,131,791 bp  Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 6: 167.27 – 167.32 Mb Chr 17: 13.11 – 13.13 Mb PubMed search   Wikidata Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.
Unc93A is a
major facilitator superfamily (MFS), and a putative solute carrier in humans.  It belongs to the  atypical SLCs that was recently listed. It is therefore presumed that UNC93A is a transporter protein.
UNC93A is closely related to Unc93B1 and
UNC93A is affected by amino acid deprivation in cell cortex cultures
 and starvation in  in vivo samples.
It is expressed in neurons, with staining close to the plasma membrane.
 for functional studies in C.elegans.
References [ edit ]
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GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, May 2017
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GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, May 2017
"Human PubMed Reference:".
"Mouse PubMed Reference:".
"Entrez Gene: Unc-93 homolog A (C. elegans)".
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Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi: 10.1016/j.tips.2016.11.008. PMID 27939446.
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Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi: 10.1098/rsob.170142. PMC . 5627054 PMID 28878041.
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Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi: 10.3389/fnmol.2017.00351. PMC . 5671512 PMID 29163028.
Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS One. 11 (6): e0156912. doi: 10.1371/journal.pone.0156912. PMC . 4896477 PMID 27272503.
Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi: 10.1083/jcb.117.1.143. PMC . 2289394 PMID 1313436.
de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. PMID 14534247.
Further reading [ edit ]