The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The AUM is believed to be involved in strengthening the cells that line the bladder, and in enhancing the inner bladder membrane's ability to stretch, thus preventing these cells from rupturing during bladder distension. The use of alternate polyadenylation sites has been found for this gene.
Wu XR, Medina JJ, Sun TT (1996). "Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells". J. Biol. Chem. 270 (50): 29752–9. doi:10.1074/jbc.270.50.29752. PMID8530366.
Finch JL, Webb GC, Evdokiou A, Cowled PA (1997). "Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism". Genomics. 40 (3): 501–3. doi:10.1006/geno.1996.4589. PMID9073521.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Yuasa T, Yoshiki T, Tanaka T, et al. (1998). "Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma". Jpn. J. Cancer Res. 89 (9): 879–82. doi:10.1111/j.1349-7006.1998.tb00643.x. PMID9818021.