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Available structures
PDBOrtholog search: PDBe RCSB
AliasesUSO1, P115, TAP, VDP, USO1 vesicle transport factor
External IDsOMIM: 603344 MGI: 1929095 HomoloGene: 2754 GeneCards: USO1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for USO1
Genomic location for USO1
Band4q21.1Start75,724,593 bp[1]
End75,814,286 bp[1]
RNA expression pattern
PBB GE VDP 201832 s at fs.png

PBB GE VDP 201831 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 75.72 – 75.81 MbChr 5: 92.14 – 92.2 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.[5][6][7][8][9][10]


The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GOLGA2, and giantin in a sequential manner.[10]


USO1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138768 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029407 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sohda M, Misumi Y, Yano A, Takami N, Ikehara Y (March 1998). "Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane". J Biol Chem. 273 (9): 5385–8. doi:10.1074/jbc.273.9.5385. PMID 9478999.
  6. ^ Nakamura N, Lowe M, Levine TP, Rabouille C, Warren G (June 1997). "The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner". Cell. 89 (3): 445–55. doi:10.1016/S0092-8674(00)80225-1. PMID 9150144.
  7. ^ Whyte JR, Munro S (June 2002). "Vesicle tethering complexes in membrane traffic". J Cell Sci. 115 (Pt 13): 2627–37. PMID 12077354.
  8. ^ Short B, Haas A, Barr FA (June 2005). "Golgins and GTPases, giving identity and structure to the Golgi apparatus". Biochim Biophys Acta. 1744 (3): 383–95. doi:10.1016/j.bbamcr.2005.02.001. PMID 15979508.
  9. ^ Puthenveedu MA, Linstedt AD (February 2004). "Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis". Proc Natl Acad Sci U S A. 101 (5): 1253–6. doi:10.1073/pnas.0306373101. PMC 337039. PMID 14736916.
  10. ^ a b "Entrez Gene: VDP vesicle docking protein p115".
  11. ^ a b c d Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
  12. ^ a b c Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.

Further reading[edit]