USP16

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USP16
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases USP16, UBP-M, UBPM, ubiquitin specific peptidase 16
External IDs MGI: 1921362 HomoloGene: 38183 GeneCards: USP16
RNA expression pattern
PBB GE USP16 218386 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006447
NM_001001992
NM_001032410

NM_024258

RefSeq (protein)

NP_001001992
NP_001027582
NP_006438

NP_077220.2
NP_077220

Location (UCSC) Chr 21: 29.02 – 29.05 Mb Chr 16: 87.45 – 87.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.[3][4]

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  4. ^ a b "Entrez Gene: USP16 ubiquitin specific peptidase 16". 

Further reading[edit]