USP8

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USP8
Protein USP8 PDB 1whb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8
External IDs MGI: 1934029 HomoloGene: 3782 GeneCards: USP8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128610
NM_001128611
NM_001283049
NM_005154

NM_001252580
NM_019729

RefSeq (protein)

NP_001122082
NP_001269978
NP_005145

NP_062703.2
NP_001239509
NP_062703

Location (UCSC) Chr 15: 50.42 – 50.51 Mb Chr 2: 126.71 – 126.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[3][4][5]


Interactions[edit]

USP8 has been shown to interact with RNF41[6] and STAM2.[7][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  4. ^ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025. 
  5. ^ "Entrez Gene: USP8 ubiquitin specific peptidase 8". 
  6. ^ Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. United States. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982Freely accessible. PMID 15314180. 
  7. ^ Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. United States. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. ISSN 0021-9258. PMID 13129930. 
  8. ^ Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. UNITED STATES. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817. 

Further reading[edit]