USP8

USP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WHB, 2A9U, 2GFO, 2GWF, 3N3K
Identifiers
Aliases	USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDs	OMIM: 603158; MGI: 1934029; HomoloGene: 3782; GeneCards: USP8; OMA:USP8 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	50,514,421 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	126,601,217 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; ventricular zone; ; testicle; ; rectum; ; monocyte; ; caput epididymis; ; corpus epididymis; ; gallbladder;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; tail of embryo; ; genital tubercle; ; right kidney; ; stroma of bone marrow; ; zygote; ; deep cerebellar nuclei; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; SH3 domain binding; thiol-dependent deubiquitinase; peptidase activity; protein binding; cysteine-type endopeptidase activity; hydrolase activity; cadherin binding;
Cellular component	cytoplasm; endosome; membrane; plasma membrane; extrinsic component of endosome membrane; midbody; endosome membrane; extrinsic component of plasma membrane; nucleus; postsynaptic density; dendritic spine; early endosome; cytosol; glutamatergic synapse;
Biological process	protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process; mitotic cytokinesis; endosome organization; proteolysis; protein K63-linked deubiquitination; cell cycle; cell population proliferation; protein deubiquitination; cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; positive regulation of canonical Wnt signaling pathway; Ras protein signal transduction; regulation of protein stability; regulation of protein localization; regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9101
	84092
	ENSG00000138592
	ENSMUSG00000027363
	P40818
	Q80U87
	NM_001128610; NM_001128611; NM_001283049; NM_005154
	NM_001252580; NM_019729
	NP_001122082; NP_001269978; NP_005145
	NP_001239509; NP_062703
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

USP8 has been shown to interact with RNF41^[8] and STAM2.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027363 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
^ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
^ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
^ Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17). United States: 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982. PMID 15314180. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. 278 (48). United States: 48162–8. doi:10.1074/jbc.M306677200. ISSN 0021-9258. PMID 13129930. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48). UNITED STATES: 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading