From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ubiquitin specific peptidase 9, X-linked
Symbols USP9X ; DFFRX; FAF; FAM; MRX99
External IDs OMIM300072 MGI894681 HomoloGene3418 GeneCards: USP9X Gene
EC number
RNA expression pattern
PBB GE USP9X 201099 at tn.png
PBB GE USP9X 201100 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8239 22284
Ensembl ENSG00000124486 ENSMUSG00000031010
UniProt Q93008 P70398
RefSeq (mRNA) NM_001039590 NM_009481
RefSeq (protein) NP_001034679 NP_033507
Location (UCSC) Chr X:
41.09 – 41.24 Mb
Chr X:
13.07 – 13.17 Mb
PubMed search [1] [2]

Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the USP9X gene.[1][2]


This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation.


USP9X has been shown to interact with:


  1. ^ Jones MH, Furlong RA, Burkin H, Chalmers IJ, Brown GM, Khwaja O, Affara NA (Mar 1997). "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2". Hum. Mol. Genet. 5 (11): 1695–701. doi:10.1093/hmg/5.11.1695. PMID 8922996.  Check date values in: |year= / |date= mismatch (help)
  2. ^ "Entrez Gene: USP9X ubiquitin specific peptidase 9, X-linked". 
  3. ^ a b Taya S, Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K (Dec 1999). "The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin". Genes Cells 4 (12): 757–67. doi:10.1046/j.1365-2443.1999.00297.x. PMID 10620020. 
  4. ^ a b Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (Apr 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". Biochem. J. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. 
  5. ^ Taya S, Yamamoto T, Kano K, Kawano Y, Iwamatsu A, Tsuchiya T, Tanaka K, Kanai-Azuma M, Wood SA, Mattick JS, Kaibuchi K (Aug 1998). "The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme". J. Cell Biol. 142 (4): 1053–62. doi:10.1083/jcb.142.4.1053. PMC 2132865. PMID 9722616. 

Further reading[edit]