UTY (gene)

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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesUTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDsOMIM: 400009 GeneCards: UTY
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr Y: 13.23 – 13.48 Mbn/a
PubMed search[2]n/a
View/Edit Human

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.[3][4][5]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]


UTY has been shown to interact with TLE1[6] and WDR90.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183878 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031. S2CID 9994966.
  4. ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
  5. ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
  6. ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
  7. ^ "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07.

Further reading[edit]