UTY (gene)

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Available structures
PDB Human UniProt search: PDBe RCSB
Aliases UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
External IDs GeneCards: UTY
RNA expression pattern
PBB GE UTY 210322 x at fs.png

PBB GE UTY 208067 x at fs.png

PBB GE UTY 211149 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr Y: 13.25 – 13.48 Mb n/a
PubMed search [1] n/a
View/Edit Human

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.[2][3][4]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]


UTY (gene) has been shown to interact with TLE1,[5] and WDR90[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P (Jan 1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat Genet. 14 (4): 474–478. doi:10.1038/ng1296-474. PMID 8944031. 
  3. ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (May 1998). "The UTX gene escapes X inactivation in mice and humans". Hum Mol Genet. 7 (4): 737–742. doi:10.1093/hmg/7.4.737. PMID 9499428. 
  4. ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked". 
  5. ^ Grbavec, D; Lo R; Liu Y; Greenfield A; Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. ENGLAND. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. ISSN 0264-6021. PMC 1219929Freely accessible. PMID 9854018. 
  6. ^ "STRING: functional protein association networks". string-db.org. Retrieved 2015-05-07. 

Further reading[edit]