The camp was opened in May 1942 as a detention camp for girls, aged 16 to 21, who were considered criminal or difficult. Girls who reached the upper age limit were transferred to the Ravensbrück women's camp. Camp administration was provided by the Ravensbrück camp. In its early years, the head overseer at Uckermark was a woman named Lotte Toberentz, and one other Aufseherin (female warden) is known today by name, Johanna Braach. Both of these women were tried by a British court at the Third Ravensbruck Trial.
In January 1945, the juveniles' camp was closed and the infrastructure was subsequently used as an extermination camp for "women who were sick, no longer efficient, and over 52 years old". Over 5,000 women were murdered there; only 500 women and children survived. Though it was shut down in March 1945 the Soviets liberated the camp on the night of April 29–30, 1945. Today only very few structures of the camp lie in ruins, barely recognizable.